Toshimitsu Niwa Selected Research

imidazolone

9/2011	Accumulation of renin and imidazolone in peritubular capillary endothelial cells in insulin-resistant hypertensive rats.
5/2003	Increased levels of advanced glycation end products in human cataractous lenses.
3/2003	Are advanced glycation end products cardiovascular risk factors in patients with CRF?

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Toshimitsu Niwa Research Topics

Disease

33	Chronic Renal Insufficiency 01/2022 - 07/2004
15	Fibrosis (Cirrhosis) 01/2022 - 01/2002
14	Cardiovascular Diseases (Cardiovascular Disease) 06/2017 - 01/2010
14	Chronic Kidney Failure (Chronic Renal Failure) 11/2011 - 04/2002
8	Uremia 01/2014 - 06/2001
6	Inflammation (Inflammations) 11/2017 - 01/2002
4	Renal Insufficiency (Renal Failure) 01/2020 - 01/2002
4	Sclerosis 01/2012 - 01/2002
2	Hypertrophy 01/2022 - 06/2008
2	Sarcopenia 06/2017 - 11/2016
2	Insulin Resistance 01/2017 - 05/2009
2	Neoplasms (Cancer) 01/2016 - 07/2005
2	Hypertension (High Blood Pressure) 03/2013 - 09/2011
2	Macular Degeneration (Age-Related Maculopathy) 12/2010 - 09/2007
2	Atherosclerosis 05/2009 - 01/2007
2	Kidney Diseases (Kidney Disease) 07/2008 - 07/2006
2	Diabetic Nephropathies (Diabetic Nephropathy) 08/2007 - 03/2003
2	Cataract (Cataracts) 09/2006 - 05/2003
2	Type 2 Diabetes Mellitus (MODY) 03/2003 - 01/2002
1	Heart Failure 01/2022
1	Vascular Calcification 01/2020
1	Muscular Atrophy (Muscle Atrophy) 12/2017
1	Hyperuricemia 01/2017
1	Mitochondrial Diseases (Mitochondrial Disease) 11/2016
1	Nausea 01/2016
1	Vomiting 01/2016
1	Left Ventricular Dysfunction 03/2013
1	Coronary Artery Disease (Coronary Atherosclerosis) 02/2013
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2013
1	Anemia 01/2013
1	Arteriosclerosis 09/2012
1	Choroidal Neovascularization 01/2012
1	Body Weight (Weight, Body) 01/2012
1	Glucose Intolerance 09/2011
1	Arteriosclerosis Obliterans 05/2009
1	Stroke (Strokes) 05/2009
1	Coronary Disease (Coronary Heart Disease) 05/2009
1	Infections 07/2008

Drug/Important Bio-Agent (IBA)

36	IndicanIBA 01/2022 - 01/2002
14	AST 120IBA 01/2020 - 01/2002
13	Uremic ToxinsIBA 01/2020 - 01/2002
8	Proteins (Proteins, Gene)FDA Link 11/2013 - 09/2006
7	Advanced Glycation End ProductsIBA 08/2007 - 03/2003
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2008
5	C-Reactive ProteinIBA 12/2010 - 07/2004
4	GalactosidasesIBA 01/2012 - 11/2010
3	imidazoloneIBA 09/2011 - 03/2003
3	Transforming Growth Factor beta1 (TGF beta 1)IBA 02/2010 - 03/2002
3	pentosidineIBA 01/2007 - 03/2003
3	N(6)-carboxymethyllysine (carboxymethyllysine)IBA 05/2003 - 03/2003
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 11/2017 - 01/2012
2	CarbonIBA 06/2017 - 11/2010
2	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 09/2011
2	ReninIBA 05/2014 - 09/2011
2	Tissue Inhibitor of Metalloproteinase-1IBA 02/2010 - 03/2002
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2009 - 01/2008
2	Transforming Growth Factors (Transforming Growth Factor)IBA 06/2008 - 03/2002
2	EnzymesIBA 03/2008 - 07/2005
2	CreatinineIBA 01/2007 - 07/2006
1	SaltsIBA 01/2022
1	InflammasomesIBA 01/2022
1	CaspasesIBA 01/2020
1	Adenine FDA LinkGeneric 01/2020
1	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 01/2020
1	indoleIBA 06/2017
1	Xanthine OxidaseIBA 01/2017
1	AdipokinesIBA 01/2017
1	Febuxostat FDA Link 01/2017
1	Thromboplastin (Tissue Factor)IBA 01/2017
1	Plasminogen Activators (Plasminogen Activator)IBA 01/2017
1	Adenosine Triphosphate (ATP)IBA 11/2016
1	Angiotensin-Converting Enzyme 2IBA 01/2016
1	AngiotensinsIBA 01/2016
1	Prorenin ReceptorIBA 05/2014
1	omega-Chloroacetophenone (Mace)IBA 01/2014
1	Interleukin-6 (Interleukin 6)IBA 01/2014
1	AngiotensinogenIBA 04/2013
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 02/2013
1	Erythropoietin FDA Link 01/2013
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2012
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2012
1	Retinoblastoma ProteinIBA 01/2012
1	DNA (Deoxyribonucleic Acid)IBA 01/2012
1	Tyrosine (L-Tyrosine)FDA Link 01/2012
1	Small Interfering RNA (siRNA)IBA 01/2012
1	beta-Galactosidase (Lactaid)IBA 01/2012
1	Pyruvaldehyde (Methylglyoxal)IBA 09/2011
1	Cyclin-Dependent Kinase Inhibitor p16IBA 01/2011
1	Serine (L-Serine)FDA Link 12/2010
1	Peptide Hydrolases (Proteases)FDA Link 12/2010
1	CollagenIBA 02/2010
1	ResistinIBA 05/2009
1	Immunoglobulin G (IgG)IBA 07/2008

Therapy/Procedure

3	Therapeutics 01/2016 - 03/2002
2	Nephrectomy 01/2012 - 01/2008
2	Peritoneal Dialysis 01/2012 - 09/2004
2	Renal Dialysis (Hemodialysis) 01/2005 - 07/2004
1	Conservative Treatment 06/2017
1	Drug Therapy (Chemotherapy) 01/2016
1	Lasers (Laser) 07/2008